| ncRNA name | HIF-2α siRNA |
| ncRNA Category | siRNA |
| Disease name | age-related macular degeneration (AMD) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cell line ARPE-19 |
| Methods | siRNA transfection, immunoblot, qPCR, GeneChip and PCR array |
| Expression pattern | associated |
| Functional description | Co-transfection of HIF-1α siRNA and HIF-2α siRNA augmented downregulation of VEGF mRNA and protein in hypoxic RPE cells and inhibited formation of tube-like structures in HUVEC. Not only VEGF, but also expression of other angiogenic genes were synergistically downregulated by co-transfection of hypoxic RPE cells with HIF-1α and HIF-2α siRNAs. |
| PubMed ID | 23873332 |
| Year | 2013 |
| Title | Concerted inhibition of HIF-1α and -2α expression markedly suppresses angiogenesis in cultured RPE cells. |
| Drug-related ncRNA | NO |
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